PET-CT and Occupational Exposure in Oncological Patients

Mikhail Osipov, Andrey Vazhenin, Anna Kuznetsova, Irina Aksenova, Daria Vazhenina, Mikhail Sokolnikov


The paper describes the results of retrospective epidemiological study on low dose effects of diagnostic radiation exposure to humans. The data used in the study has been collected from archives of Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine during the project for creating the local electronic database of Ozyorsk patients examined with computed tomography (CTDB). The study group consisted of oncological patients who have received positron-emission computed tomography (PET-CT). All patients in the study group were residents of Ozyorsk – the town in South Ural where the “Mayak” production association, also known as 1st Russian nuclear enterprise is located. The main purpose of the study was to understand whether the number of PET-CT scans, as well as other radiation risk factors influences the mortality in the exposed group. The follow-up period started in 2010 since the first PET-CT scans has been performed, and ended in June, 2019. Radiation dose for oncological patients exposed to PET-CT has been compared with the cumulative dose from occupational exposure. Vital status and cause of death of patients who died to the end of follow-up has been established using the data of National Cancer Registry in part located in the Chelyabinsk Regional Clinical Center of Oncology and Nuclear Medicine. Cancer mortality has been analysed depending on age of patient, sex, number of PET-CT examinations, and presence of occupational exposure, using the logistic regression model. Main radiation risk factors influencing cancer mortality has been established.


PET; CT; Nuclear Workers; Cancer; Medical Exposure; Radiation Risk.


Charron, M., Beyer, T., Bohnen, N. N., Kinahan, P. E., Dachille, M., Jerin, J., … Townsend, D. W. (2000). Image Analysis in Patients with Cancer Studied with a Combined PET and CT Scanner. Clinical Nuclear Medicine, 25(11), 905–910. doi:10.1097/00003072-200011000-00010.

Brix, G., Nekolla, E. A., Borowski, M., & Noßke, D. (2013). Radiation risk and protection of patients in clinical SPECT/CT. European Journal of Nuclear Medicine and Molecular Imaging, 41(S1), 125–136. doi:10.1007/s00259-013-2543-3

Fomin, E.P., and M.V. Osipov. “Pooled Database Of Ozyorsk Population Exposed To Computed Tomography.” Russian Electronic Journal of Radiology 9, no. 2 (2019): 234–239. doi:10.21569/2222-7415-2019-9-2-234-239.

Koshurnikova, N. A., Shilnikova, N. S., Okatenko, P. V., Kreslov, V. V., Bolotnikova, M. G., Sokolnikov, M. E., … Romanov, S. A. (1999). Characteristics of the Cohort of Workers at the Mayak Nuclear Complex. Radiation Research, 152(4), 352. doi:10.2307/3580220.

Valentin, J. (1998). Radiation dose to patients from radiopharmaceuticals: (Addendum 2 to ICRP Publication 53) ICRP Publication 80 Approved by the Commission in September 1997. Annals of the ICRP, 28(3), 1–1. doi:10.1016/s0146-6453(99)00006-8.

Basic Sanitary Rules for Radiation Safety OSPORB-99/2010. SP (in Russian). Available online: (accessed on 31 March 2020).

Kohler U., Kreute F. (2005). Data analysis using Stata. USA, Texas: Statapress.

Shilnikova N. S., Preston D. L., Ron E., Gilbert E. S., Vassilenko E. K., Romanov S. A., Kuznetsova I. S., Sokolnikov M. E., Okatenko P. V., Kreslov V. V. Koshurnikova N. A. (2003). Cancer Mortality Risk among Workers at the Mayak Nuclear Complex. Radiation Research 159, 787–798. doi: 10.1667/0033-7587(2003)159[0787:cmrawa];2

Osipov, M. V., Vazhenin, A. V., Domozhirova, A. S., Chernova, O. N., … Aksenova, I. A. (2019). Computed Tomography As A Risk Factor In Cancer Patients With Professional Radiation Exposure. Russian Electronic Journal of Radiology, 9(1), 142–147. doi:10.21569/2222-7415-2019-9-1-142-147.

Osipov M.V., Sokolnikov M.E. Fomin E.P. (2018). Prospects for using the medical dosimetric register of computed tomography to assess the contribution of medical diagnostic radiation to radiogenic risk. Issues of Radiation Safety, 89 (1): 67-73. (in Russian).

Bray F., Colombet M., Mery L., Piñeros M, Znaor A, Zanetti R, Ferlay J. Cancer Incidence in Five Continents, Vol. XI. Lyon: International Agency for Research on Cancer. Available online: (accessed on 31 March 2020).

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DOI: 10.28991/SciMedJ-2020-0202-3


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