1. Home
  2. Vol 3, No 1 (2021)
  3. Serwaa

Prevalence and Determinant of Erectile Dysfunction in Type II Diabetes Mellitus and Healthy Men

Dorcas Serwaa, Folasade Adenike Bello, Kayode O. Osungbade, Charles Nkansah

Abstract


Erectile dysfunction is currently a growing health concern and one of the most prevalent sexual dysfunctions in men worldwide. Diabetes mellitus is considered a risk factor for developing ED. Therefore, this SHIM study was designed to assess the prevalence, severity and determinant of erectile dysfunction in type II diabetes mellitus patients and healthy men. This hospital-based cross-sectional study was conducted on 132 diabetic male patients and 66 healthy men at the Nkenkaasu hospital, Offinso North, Ghana between January-June, 2019. A pre-structured questionnaire and patients’ medical records were used to document relevant information. Erectile function was assessed using Sexual health inventory for men questionnaire. Data were analyzed using SPSS version 22.0. Chi-square test, binary and multivariable logistic regression analysis were used appropriately. The mean age of study participants was 57.94 ± 9.79 years. The overall mean score on the SHIM test was 12.42 ± 8.15 (range: 1–25), mean of 9.59±7.83 for the type II diabetics and 18.08±5.39 for non-diabetic men. The total erectile dysfunction (ED) prevalence was 81.8% (95% CI: 0.757, 0.869). ED was common in diabetics (70.4%) compared with healthy men (29.6%). Severe ED was 93.7% and 6.3% in the diabetic and non-diabetic men respectively. Multivariate logistic regression revealed that diabetic men with poor health-related quality of life had 3.48 times likelihood of having ED compared to their non-diabetic counterparts (AOR= 3.48, 95% CI; 1.284, 9.453). Very high erectile dysfunction was observed in our study participants. This is worrisome owing to the profound negative impact of ED on the quality of life and fertility of men. It is recommended that periodic assessment of erectile function should form part of routine diabetes care, focusing attention on the modifiable risk factors in preventing, delaying progression, or reversing established ED in persons.

 

Doi: 10.28991/SciMedJ-2021-0301-4

Full Text: PDF


Keywords


Prevalence; Determinants; Erectile Dysfunction; Type II Diabetes Mellitus.

References


Lue, T. F. (2000). Erectile Dysfunction. New England Journal of Medicine, 342(24), 1802–1813. doi:10.1056/nejm200006153422407

Johannes, C. B., Araujo, A. B., Feldman, H. A., Derby, C. A., Kleinman, K. P., & McKinlay, J. B. (2000). Incidence of Erectile Dysfunction in Men 40 To 69 Years Old: Longitudinal Results from the Massachusetts Male Aging Study. Journal of Urology, 163(2), 460–463. doi:10.1016/s0022-5347(05)67900-1

Ariba, A., Oladapo, O., Iyaniwura, C., & Dada, O. (2007). Management of erectile dysfunction: perceptions and practices of Nigerian primary care clinicians. South African Family Practice, 49(9), 16–16d. doi:10.1080/20786204.2007.10873632.

McVary, K. T., Carrier, S., & Wessells, H. (2001). Smoking and Erectile Dysfunction: Evidence Based Analysis. Journal of Urology, 166(5), 1624–1632. doi:10.1016/s0022-5347(05)65641-8

Sasayama, S., Ishii, N., Ishikura, F., Kamijima, G., Ogawa, S., Kanmatsuse, K., ... & Yamamoto, Y. (2003). Men's Health Study: epidemiology of erectile dysfunction and cardiovascular disease. Circulation journal, 67(8), 656-659. doi:10.1253/circj.67.656.

Grover, S. A., Lowensteyn, I., Kaouache, M., Marchand, S., Coupal, L., DeCarolis, E., … Defoy, I. (2006). The Prevalence of Erectile Dysfunction in the Primary Care Setting: Importance of Risk Factors for Diabetes and Vascular Disease. Archives of Internal Medicine, 166(2), 213-219. doi:10.1001/archinte.166.2.213.

Yang, C.-M., Shen, Y.-C., Weng, S.-F., Wang, J.-J., & Tien, K.-J. (2015). Increased Risk of Dementia in Patients with Erectile Dysfunction: A Population-based, Propensity Score-matched, Longitudinal Follow-up Study. Medicine, 94(24), e990. doi:10.1097/md.0000000000000990.

Moore, C. S., Grant, M. D., Zink, T. A., Panizzon, M. S., Franz, C. E., Logue, M. W., … Lyons, M. J. (2014). Erectile dysfunction, vascular risk, and cognitive performance in late middle age. Psychology and Aging, 29(1), 163–172. doi:10.1037/a0035463.

Susanti, E., Donosepoetro, M., Patellongi, I., & Arif, M. (2010). Differences between several atherogenic parameters in patients with Controlled and Uncontrolled Type 2 Diabetes Mellitus. Medical Journal of Indonesia, 19(2), 103-108. doi:10.13181/mji.v19i2.392.

Sazandeh, F. S. S. (2004). Serum ferritin in type 2 diabetes mellitus and its relationship with HbA1c. Acta Medica Iranica, 142–145.

Barsiah, S., Behnamâ€Rassouli, M., Shahabipour, F., Rostami, S., Sabbaghi, M. A., Momeni, Z., … Sahebkar, A. (2019). Evaluation of testis hormonal and histopathological alterations in type I and type II diabetic rats. Journal of Cellular Biochemistry, 120(10), 16775–16785. doi:10.1002/jcb.28936.

Shi, G.-J., Zheng, J., Wu, J., Qiao, H.-Q., Chang, Q., Niu, Y., … Yu, J.-Q. (2017). Protective effects of Lycium barbarum polysaccharide on male sexual dysfunction and fertility impairments by activating hypothalamic pituitary gonadal axis in streptozotocin-induced type-1 diabetic male mice. Endocrine Journal, 64(9), 907–922. doi:10.1507/endocrj.ej16-0430.

Owiredu, W. K., Amidu, N., Alidu, H., Sarpong, C., & Gyasi-Sarpong, C. K. (2011). Determinants of sexual dysfunction among clinically diagnosed diabetic patients. Reproductive Biology and Endocrinology, 9(1), 70. doi:10.1186/1477-7827-9-70.

Afolayan, A. J., & Yakubu, M. T. (2009). Erectile Dysfunction Management Options in Nigeria. The Journal of Sexual Medicine, 6(4), 1090–1102. doi:10.1111/j.1743-6109.2008.01064.x.

Djrolo, F., Paraïso, N. M., Diarra, O., & Makoutode, M. (2014). Diabetes Complications and Associated Factors in Type 2 Diabetic Patients in Cotonou. Journal of Diabetes Mellitus, 04(04), 311–315. doi:10.4236/jdm.2014.44043.

Krysiak, R., Gilowski, W., & Okopień, B. (2016). The effect of testosterone on cardiovascular risk factors in men with type 2 diabetes and late-onset hypogonadism treated with metformin or glimepiride. Pharmacological Reports, 68(1), 75–79. doi:10.1016/j.pharep.2015.06.003.

Seftel, A. D., Sun, P., & Swindle, R. (2004). The Prevalence of Hypertension, Hyperlipidemia, Diabetes Mellitus and Depression in Men with Erectile Dysfunction. Journal of Urology, 171(6 Part 1), 2341–2345. doi:10.1097/01.ju.0000125198.32936.38.

Gauthaman, K., Adaikan, P. ., & Prasad, R. N. V. (2002). Aphrodisiac properties of Tribulus Terrestris extract (Protodioscin) in normal and castrated rats. Life Sciences, 71(12), 1385–1396. doi:10.1016/s0024-3205(02)01858-1.

Sondhi, M., Kakar, A., Gogia, A., & Gupta, M. (2018). Prevalence of erectile dysfunction in diabetic patients. Current Medicine Research and Practice, 8(3), 88–91. doi:10.1016/j.cmrp.2018.05.005.

Frimpong Manso, S., Magnus Aryitey, G. T., Hevi, D., Dombi, G., Nyarko, A. K., Boamah, D., & Awan, M. (2016). Bioinorganic elemental content of the Ghanaian aphrodisiac medicinal plant, Paullina pinnata Linn. (Sapindaceae). African Journal of Pharmacy and Pharmacology, 10(11), 206–211. doi:10.5897/ajpp2015.4417.

Burd, I. D., Nevadunsky, N., & Bachmann, G. (2006). Original Research—Education: Impact of Physician Gender on Sexual History Taking in a Multispecialty Practice. The Journal of Sexual Medicine, 3(2), 194–200. doi:10.1111/j.1743-6109.2005.00168.x.

Rhoden, E. L., Telöken, C., Sogari, P. R., & Vargas Souto, C. A. (2002). The use of the simplified International Index of Erectile Function (IIEF-5) as a diagnostic tool to study the prevalence of erectile dysfunction. International Journal of Impotence Research, 14(4), 245–250. doi:10.1038/sj.ijir.3900859.

Offinso north district, G. S. S. (2014). Ghana statistical service, 2010 population and housing Census, District Analytical Report, Offinso North District. Available online: http://www2.statsghana.gov.gh/docfiles/2010_District_Report/ Ashanti/Offinso North.pdf (accessed on September 2020).

Atlas, I. D. (2017). Brussels, Belgium: international diabetes federation; 2013. International Diabetes Federation (IDF), 147.

Larsson, C. A., Krøll, L., Bennet, L., Gullberg, B., Råstam, L., & Lindblad, U. (2012). Leisure time and occupational physical activity in relation to obesity and insulin resistance: a population-based study from the Skaraborg Project in Sweden. Metabolism, 61(4), 590–598. doi:10.1016/j.metabol.2011.09.010.

Jia, H., & Lubetkin, E. I. (2005). The impact of obesity on health-related quality-of-life in the general adult US population. Journal of Public Health, 27(2), 156–164. doi:10.1093/pubmed/fdi025.

Rautio, N., Varanka-Ruuska, T., Vaaramo, E., Palaniswamy, S., Nedelec, R., Miettunen, J., … Ala-Mursula, L. (2017). Accumulated exposure to unemployment is related to impaired glucose metabolism in middle-aged men: A follow-up of the Northern Finland Birth Cohort 1966. Primary Care Diabetes, 11(4), 365–372. doi:10.1016/j.pcd.2017.03.010.

Hu, F. B., Manson, J. E., Stampfer, M. J., Colditz, G., Liu, S., Solomon, C. G., & Willett, W. C. (2001). Diet, Lifestyle, and the Risk of Type 2 Diabetes Mellitus in Women. New England Journal of Medicine, 345(11), 790–797. doi:10.1056/nejmoa010492.

Virtanen, M., Ferrie, J. E., Tabak, A. G., Akbaraly, T. N., Vahtera, J., Singh-Manoux, A., & Kivimäki, M. (2014). Psychological Distress and Incidence of Type 2 Diabetes in High-Risk and Low-Risk Populations: The Whitehall II Cohort Study. Diabetes Care, 37(8), 2091–2097. doi:10.2337/dc13-2725.

Bertrais, S., Beyeme-Ondoua, J.-P., Czernichow, S., Galan, P., Hercberg, S., & Oppert, J.-M. (2005). Sedentary Behaviors, Physical Activity, and Metabolic Syndrome in Middle-aged French Subjects. Obesity Research, 13(5), 936–944. doi:10.1038/oby.2005.108.

Li, C.-L., Lin, J.-D., Lee, S.-J., & Tseng, R.-F. (2007). Associations between the metabolic syndrome and its components, watching television and physical activity. Public Health, 121(2), 83–91. doi:10.1016/j.puhe.2006.08.004.

Irwin, G. M. (2019). Erectile Dysfunction. Primary Care: Clinics in Office Practice, 46(2), 249–255. doi:10.1016/j.pop.2019.02.006.

Ziaei-Rad, M., Vahdaninia, M., & Montazeri, A. (2010). Sexual dysfunctions in patients with diabetes: a study from Iran. Reproductive Biology and Endocrinology, 8(1), 50. doi:10.1186/1477-7827-8-50.

Selvin, E., Burnett, A. L., & Platz, E. A. (2007). Prevalence and Risk Factors for Erectile Dysfunction in the US. The American Journal of Medicine, 120(2), 151–157. doi:10.1016/j.amjmed.2006.06.010.

Dong, J.-Y., Zhang, Y.-H., & Qin, L.-Q. (2011). Erectile Dysfunction and Risk of Cardiovascular Disease. Journal of the American College of Cardiology, 58(13), 1378–1385. doi:10.1016/j.jacc.2011.06.024.

Seid, A., Gerensea, H., Tarko, S., Zenebe, Y., & Mezemir, R. (2017). Prevalence and determinants of erectile dysfunction among diabetic patients attending in hospitals of central and northwestern zone of Tigray, northern Ethiopia: a cross-sectional study. BMC Endocrine Disorders, 17(1): 1-7. doi:10.1186/s12902-017-0167-5.

Esposito, K., Giugliano, F., Di Palo, C., Giugliano, G., Marfella, R., D’Andrea, F., … Giugliano, D. (2004). Effect of Lifestyle Changes on Erectile Dysfunction in Obese Men. JAMA, 291(24), 2978. doi:10.1001/jama.291.24.2978.


Full Text: PDF

DOI: 10.28991/SciMedJ-2021-0301-4

Refbacks

  • There are currently no refbacks.


Copyright (c) 2021 Dorcas Serwaa, Folasade Adenike Bello, Kayode O. Osungbade, Charles Nkansah