The Prevalence of blaNDM-1 in Clinical Isolates of Carbapenem-resistant Pseudomonas Aeruginosa: A Systematic Review

Bea Jorelli U. Fernando; Ma. Oryza B. Antonio; Ken Matthew A. De Guzman; Jan Carlo Y. Gatbonton; Sunshine T. Vendivil; Raphael Enrique G. Tiongco; Sherill D. Tesalona

doi:10.28991/SciMedJ-2021-0304-9

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Bea Jorelli U. Fernando
beajorelli.fernando.pharma@ust.edu.ph
Department of Medical Technology, Faculty of Pharmacy, University of Santo Tomas, España Blvd, Sampaloc, Manila,, Philippines
Ma. Oryza B. Antonio Department of Medical Technology, Faculty of Pharmacy, University of Santo Tomas, España Blvd, Sampaloc, Manila,, Philippines
Ken Matthew A. De Guzman Department of Medical Technology, Faculty of Pharmacy, University of Santo Tomas, España Blvd, Sampaloc, Manila,, Philippines
Jan Carlo Y. Gatbonton Department of Medical Technology, Faculty of Pharmacy, University of Santo Tomas, España Blvd, Sampaloc, Manila,, Philippines
Sunshine T. Vendivil Department of Medical Technology, Faculty of Pharmacy, University of Santo Tomas, España Blvd, Sampaloc, Manila,, Philippines
Raphael Enrique G. Tiongco Department of Medical Technology, College of Allied Medical Professions, Angeles University Foundation, Angeles City,, Philippines
Sherill D. Tesalona Department of Medical Technology, Faculty of Pharmacy, University of Santo Tomas, España Blvd, Sampaloc, Manila,, Philippines

Vol. 3 No. 4 (2021): December

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Background: Pseudomonas aeruginosa (P. aeruginosa) is a gram negative bacteria that is known to cause nosocomial infections. Carbapenem is used to treat the damage caused by P. aeruginosa, however it is becoming resistant to carbapenems because of the production of lactamases. The objectives of the study were to systematically review the prevalence of bla_NDM-1 in carbapenem-resistant Pseudomonas aeruginosa (CRPA) and to review and analyze the clinical sources as well as the antibiotic resistance profile of CRPA carrying bla_NDM-1. Methods: The researchers systematically searched PubMed, ScienceDirect, and Google Scholar. Studies that met the inclusion criteria were included in the review. In assessing the methodological quality of the included studies, the JBI Critical Appraisal Checklist for Studies Reporting Prevalence Data and the JBI Critical Appraisal Checklist for Case Reports were used. Results: A total of nine studies were included in which eight were cross-sectional studies and one was a case report. The highest prevalence rate reported was 54.55% in bla_NDM-1 positive CRPA isolates among the cross-sectional studies. The three most frequent sources of clinical isolates of CRPA carrying bla_NDM-1 include urine, wound discharge, and tissue, among the included studies. Lastly, this review showed that among the included studies, CRPA isolates carrying bla_NDM-1 were most resistant to ceftazidime and gentamicin. Conclusions: There is varying prevalence of bla_NDM-1 in CRPA in different countries. Urine, wound discharge, and tissue specimens being the most frequent sources of CRPA isolates carrying bla_NDM-1 poses a challenge that must be given attention by the infection control committee, thus the need for proper handling and processing of clinical specimens. Resistance to ceftazidime and gentamicin among the CRPA isolates carrying bla_NDM-1highlights the growing challenge of successfully treating infections caused by this bacteria. This challenge reminds us of the importance and purpose of antibiotic stewardship that emphasizes the improvement of proper antibiotic prescription by the physicians and proper antibiotic use by the patients that can help in preventing harm and antibiotic resistance.

Doi: 10.28991/SciMedJ-2021-0304-9

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The Prevalence of blaNDM-1 in Clinical Isolates of Carbapenem-resistant Pseudomonas Aeruginosa: A Systematic Review

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