A Mini Review on SARS-COVID-19-2 Omicron Variant (B.1.1.529)

Santhosh Kumar Ettaboina, Komalatha Nakkala, K. S. Laddha


The current world facing unpredictable problems with different variants of COVID-19; SARS-COV-19 is a significant lung infection caused by a coronavirus. Each type has one or more alterations to distinguish from each other. The viruses, including SARS-COV-19, continuously change the genetic code (mutations) during their genome replication. WHO labelled two variants in that we are experienced with delta (B.1.617.2) variant, now recently the omicron came (B.1.1.529) with highly mutatable strikes on it. So WHO predicted it is more dangerous than previous variants because of its mutatable capability. The mutatable strikes play an essential role in transmissibility. So there is a need to evaluate threatens raised with the new variant, so scientists are working on it. Till now, South Africa noticed major cases positive for the Omicron variant. Based on recent reports, the current paper summarized different properties of the omicron variant with others, including protein structure, diagnosis, spreadability, treatment, and potency of vaccines.


Doi: 10.28991/SciMedJ-2021-0304-10

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COVID-19; Delta Variant (B.1.617.2); Omicron (B.1.1.529); Spredability; Treatment.


Cowling, B. J., Park, M., Fang, V. J., Wu, P., Leung, G. M., & Wu, J. T. (2015). Preliminary epidemiological assessment of MERS-CoV outbreak in South Korea, may to June 2015. Eurosurveillance, 20(25), 1–7. doi:10.2807/1560-7917.ES2015.20.25.21163.

Wang, C., Horby, P. W., Hayden, F. G., &Gao, G. F. (2020). A novel coronavirus outbreak of global health concern. The Lancet, 395(10223), 470–473. doi:10.1016/S0140-6736(20)30185-9.

Cascella, M., Rajnik, M., Aleem, A., Dulebohn, S., & Di Napoli, R. (2021). Features, evaluation, and treatment of coronavirus (COVID-19). StatPearls (NCBI Bookshelf).

Centers for disease control and prevention CDC published SARS-CoV-2 Variant Classifications and Definitions. Available online: https://www.cdc.gov/coronavirus/2019-ncov/variants/variant-classifications.html (accessed on December 2021).

Zhou, B., Thao, T. T. N., Hoffmann, D., Taddeo, A., Ebert, N., Labroussaa, F. Beer, M. (2021). SARS-CoV-2 spike D614G change enhances replication and transmission. Nature, 592(7852), 122–127. doi:10.1038/s41586-021-03361-1.

The times of India publised Covid-19: How Omicron uses spike protein to enter cells (2021). Availbale online: https://timesofindia.indiatimes.com/world/rest-of-world/covid-19-how-omicron-uses-spike-protein-to-enter-cells/articleshow/88056481.cms (accessed on December 2021)

The Hindu published First death with Omicron variant in United Kingdom (2021). Available online: https://www.thehindu.com/news/international/first-death-with-omicron-variant-in-united-kingdom/article37950265.ece (accessed on December 2021)

Krieger, B. L. M., Area, B., & Group, N. (2021). Omicron vs. Delta : Comparing COVID’s most worrisome variants (pp. 4–7).

Reuters published Explainer: How worried should we be about the Omicron variant? (2021). Available online: https://www.reuters.com/business/healthcare-pharmaceuticals/how-worried-should-we-be-about-omicron-variant-2021-12-14/ (accessed on December 2021).

Özdemir, Ö. (2020). Coronavirus Disease 2019 (COVID-19): Diagnosis and Management (narrative review). Erciyes Medical Journal, 42, 242–247. doi:10.14744/etd.2020.99836.

The Economic Times News “Bengaluru doctor infected with Omicron doing fine” (2021).Available online: https://economictimes.indiatimes.com/news/india/bengaluru-doctor-infected-with-omicron-doing-fine/articleshow/88085676.cms (accessed on December 2021).

Hindustan Times, Coronavirus digest: Omicron reported in 57 countries, WHO Reports (2021). Available online: https://www.hindustantimes.com/lifestyle/health/coronavirus-digest-omicron-reported-in-57-countries-who-reports-101639015185312.html (accessed on December 2021).

U.P.I.N. South Africa hits daily record 37,875 COVID-19 cases mostly by Omicron (2021). Available online: https://www.upi.com/Top_News/World-News/2021/12/12/coronavirus-south-africa-record-37875-cases/3181639318281/ (accessed on December 2021).

India Today, With 78,610 new patients, UK sees highest ever daily Covid cases amid Omicron spread. Available online: https://www.indiatoday.in/coronavirus-outbreak/story/covid-omicron-uk-cases-1888313-2021-12-16 (accessed on December 2021).

Hindustan Times, Coronavirus digest: Omicron reported in 57 countries, WHO Reports (2021). Available online: https://www.hindustantimes.com/lifestyle/health/coronavirus-digest-omicron-reported-in-57-countries-who-reports-101639015185312.html (accessed on December 2021).

European Centre for Disease Prevention and Control published, Epidemiological update: Omicron variant of concern (VOC) – data as of 12 December 2021. Available online: https://www.ecdc.europa.eu/en/news-events/epidemiological-update-omicron-data-12-december (accessed on December 2021).

Indian Express, Covid-19 Numbers Explained: Omicron cases in US less than 1,500 but infections could be over six lakh (2021).https://indianexpress.com/article/explained/covid-19-numbers-explained-omicron-us-cases-7683032/ (Accessed on December 2021).

Indian Express, Coronavirus News Highlights: Delhi reports nearly 500 new Covid cases, test positivity rate jumps to 0.89% (2021).https://indianexpress.com/article/india/coronavirus-news-live-omicron-modi-covid-vaccine-booster-7690706/ (accessed on December 2021).

E Times News, Coronavirus: Are children at risk of developing severe Omicron infection? Available onlinehttps://timesofindia.indiatimes.com/life-style/health-fitness/health-news/coronavirus-are-children-at-risk-of-developing-severe-omicron-infection/photostory/88141222.cms (accessed on December 2021).

Shen, K., Yang, Y., Wang, T., Zhao, D., … Jiang, Y. (2020). Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts’ consensus statement. World Journal of Pediatrics, 16(3), 223–231. doi:10.1007/s12519-020-00343-7.

Medicines, T., & Biotechnology, V. (2021). UK approves new Covid treatment, may work against Omicron variant (pp. 1–2).

The New York Times, Pfizer’s Covid Pill Works Well, Company Confirms in Final Analysis. Available online: https://www.nytimes.com/live/2021/12/14/world/covid-omicron-vaccines/pfizer-covid-pill-paxlovid (accessed on December 2021).

Baden, L. R., El Sahly, H. M., Essink, B., Kotloff, K., Frey, S., Novak, R., Diemert, D., Spector, S. A., Rouphael, N., Creech, C. B., McGettigan, J., Khetan, S., Segall, N., Solis, J., Brosz, A., Fierro, C., Schwartz, H., Neuzil, K., Corey, L., … Zaks, T. (2021). Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine. New England Journal of Medicine, 384(5), 403–416. doi:10.1056/nejmoa2035389.

Tartof, S. Y., Slezak, J. M., Fischer, H., Hong, V., Ackerson, B. K., Ranasinghe, O. N., Frankland, T. B., Ogun, O. A., Zamparo, J. M., Gray, S., Valluri, S. R., Pan, K., Angulo, F. J., Jodar, L., & McLaughlin, J. M. (2021). Effectiveness of mRNA BNT162b2 COVID-19 vaccine up to 6 months in a large integrated health system in the USA: a retrospective cohort study. The Lancet, 398(10309), 1407–1416. doi:10.1016/S0140-6736(21)02183-8.

Agency, E. M., & O, D. W. H. (2021). WHO adds Janssen vaccine to list of safe and effective emergency tools against COVID-19. Saudi Medical Journal, 42(4), 463–464.

Voysey, M., Clemens, S. A. C., Madhi, S. A., Weckx, L. Y., Folegatti, P. M., Aley, P. K., Angus, B., Baillie, V. L., Barnabas, S. L., Bhorat, Q. E., Bibi, S., Briner, C., Cicconi, P., Collins, A. M., Colin-Jones, R., Cutland, C. L., Darton, T. C., Dheda, K., Duncan, C. J. A., … Zuidewind, P. (2021). Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK. The Lancet, 397(10269), 99–111. doi:10.1016/S0140-6736(20)32661-1.

Thiagarajan, K. (2021). What do we know about India’s Covaxin vaccine? The BMJ, 373, 1–2. doi:10.1136/bmj.n997.

Zhang, Y., Zeng, G., Pan, H., Li, C., Hu, Y., Chu, K., Han, W., Chen, Z., Tang, R., Yin, W., Chen, X., Hu, Y., Liu, X., Jiang, C., Li, J., Yang, M., Song, Y., Wang, X., Gao, Q., & Zhu, F. (2021). Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine in healthy adults aged 18–59 years: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial. In The Lancet Infectious Diseases (Vol. 21, Issue 2, pp. 181–192). doi:10.1016/S1473-3099(20)30843-4.

Jara, A., Undurraga, E. A., González, C., Paredes, F., Fontecilla, T., Jara, G., Pizarro, A., Acevedo, J., Leo, K., Leon, F., Sans, C., Leighton, P., Suárez, P., García-Escorza, H., &Araos, R. (2021). Effectiveness of an Inactivated SARS-CoV-2 Vaccine in Chile. New England Journal of Medicine, 385(10), 875–884. doi:10.1056/nejmoa2107715.

Momin, T., Kansagra, K., Patel, H., Sharma, S., Sharma, B., Patel, J., Mittal, R., Sanmukhani, J., Maithal, K., Dey, A., Chandra, H., Rajanathan, C. T., Pericherla, H. P., Kumar, P., Narkhede, A., &Parmar, D. (2021). Safety and Immunogenicity of a DNA SARS-CoV-2 vaccine (ZyCoV-D): Results of an open-label, non-randomized phase I part of phase I/II clinical study by intradermal route in healthy subjects in India. In EClinicalMedicine (Vol. 38). doi:10.1016/j.eclinm.2021.101020.

Baraniuk, C. (2021). Covid-19: What do we know about Sputnik v and other Russian vaccines? The BMJ, 372, 7–8. doi:10.1136/bmj.n743.

Serum Institute of India Pvt. Ltd. (2020). COVISHIELD Completes Enrolment of Phase III clinical trials under partnership of ICMR and Serum Institute of India (pp. 1–2).

Komalatha, N., Shilpa, G., Laddha, KS. (2020). Isolation of starch from curcuma longa and its characterization. International Journal of Pharmaceutical Sciences and Research, 11(11), 5712-17. doi:10.13040/IJPSR.0975-8232.

Baswaraju, M., Komalatha, N., Anil Kumar, G., Raghuram Rao, A., Achaiah, G. (2018). Synthesis and evalution of new tacrine derivatives as anti-alzheimer’s agents. International Journal of Pharmacy and Biological Sciences, 8 (1), 590-597.

Mathieu, E., Ritchie, H., Ortiz-Ospina, E., Roser, M., Hasell, J., Appel, C., … Rodés-Guirao, L. (2021). A global database of COVID-19 vaccinations. Nature Human Behaviour, 5(7), 947–953. doi:10.1038/s41562-021-01122-8.

Dongala, T., Katari, N. K., Ettaboina, S. K., Krishnan, A., Tambuwala, M. M., & Dua, K. (2021). In vitro Dissolution Profile at Different Biological pH Conditions of Hydroxychloroquine Sulfate Tablets Is Available for the Treatment of COVID-19. Frontiers in Molecular Biosciences, 7. doi:10.3389/fmolb.2020.613393.

Katakam, L. N. R., Dongala, T., & Ettaboina, S. K. (2020). Novel stability indicating UHPLC method development and validation for simultaneous quantification of hydrocortisone acetate, pramoxine hydrochloride, potassium sorbate and sorbic acid in topical cream formulation. Talanta Open, 1, 100004. doi:10.1016/j.talo.2020.100004.

Katakam, L. N. R., Ettaboina, S. K., & Dongala, T. (2021). A simple and rapid HPLC method for determination of parabens and their degradation products in pharmaceutical dosage forms. Biomedical Chromatography, 35(10). doi:10.1002/bmc.5152.

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DOI: 10.28991/SciMedJ-2021-0304-10


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