Effects of Salvia Officinalis Extract on the Breast Cancer Cell Line
Abstract
Background: Common sage (Salvia officinalis L., Lamiaceae) is an aromatic and medicinal plant well known for its antioxidant properties. This plant belongs to Lamiaceae family and has many pharmaceutical properties. Some in vivo studies have shown the biological antioxidant effects of sage. As a member of Salvia officinalis Labiatae, sage is also known as “Maryam flower” in Iran. Sage importance lies in its therapeutic potential. It has been exploited as an anti-spasmodic, astringent, sedative, anti-hyperglycemic, and anti-inflammatory agent in Iranian medicine. Objective: Studying the anticancer effects of the compounds in Salvia officinalis extracts, such as cineol and camphor. Methods: Cancer was induced by DMBA (dimethyl-benzantheracene) dissolved in sunflower oil for 4 weeks. The case group was treated with sage leaf hydroalcoholic extract for 4 weeks; while the controls received distilled water. Result: Angiogenesis is a key process in cancer spread and metastasis. The hydroalcoholic extract of garden sage halted angiogenesis in the breast cell line of both human and mouse models; the highest impact was observed in hexane extract. Findings indicated the therapeutic effects of garden sage (i.e. its in vitro anti-angiogenesis activity and anti-migratory properties). Conclusion: Saliva officinalis can potentially prevent breast cancer.
Keywords
References
Jedinák, A., Mučková, M., Košt’álová, D., Maliar, T., & Mašterová, I. (2006). Antiprotease and Antimetastatic Activity of Ursolic Acid Isolated from Salvia officinalis. Zeitschrift Für Naturforschung C, 61(11-12), 777–782. doi:10.1515/znc-2006-11-1203.
El Hadri, A., del Rio, M. G., Sanz, J., Coloma, A. G., Idaomar, M., Ozonas, B. R., ... & Reus, M. I. S. (2010). Cytotoxic activity of α-humulene and transcaryophyllene from Salvia officinalis in animal and human tumor cells. An R Acad Nac Farm, 76(3), 343-356.
Bradley, P. (Ed.). (2006). British herbal compendium: a handbook of scientific information on widely used plant drugs. British Herbal Medicine Assoc.
Miata M, Furukawa M, Takhashi K. (2001) Mechanism of dimethylbenzantrencen-induced immune –toxicity:role of metabolic activation at the target organ. Pharmacology. (86):302-309.
Motoyama, J., Yamashita, N., Morino, T., Tanaka, M., Kobayashi, T., & Honda, H. (2008). Hyperthermic treatment of DMBA-induced rat mammary cancer using magnetic nanoparticles. BioMagnetic Research and Technology, 6(1), 2. doi:10.1186/1477-044x-6-2.
Viuda-Martos, M., Mohamady, M. A., Fernández-López, J., Abd ElRazik, K. A., Omer, E. A., Pérez-Alvarez, J. A., & Sendra, E. (2011). In vitro antioxidant and antibacterial activities of essentials oils obtained from Egyptian aromatic plants. Food Control, 22(11), 1715–1722. doi:10.1016/j.foodcont.2011.04.003.
Ebrahimabadi, A. H., Mazoochi, A., Kashi, F. J., Djafari-Bidgoli, Z., & Batooli, H. (2010). Essential oil composition and antioxidant and antimicrobial properties of the aerial parts of Salvia eremophila Boiss. From Iran. Food and Chemical Toxicology, 48(5), 1371–1376. doi:10.1016/j.fct.2010.03.003.
Kulisic, T., Radonic, A., Katalinic, V., & Milos, M. (2004). Use of different methods for testing antioxidative activity of oregano essential oil. Food Chemistry, 85(4), 633–640. doi:10.1016/j.foodchem.2003.07.024.
Kar, A., Panda, S., & Bharti, S. (2002). Relative efficacy of three medicinal plant extracts in the alteration of thyroid hormone concentrations in male mice. Journal of Ethnopharmacology, 81(2), 281–285. doi:10.1016/s0378-8741(02)00048-x.
AOCS names official referee chemists: 1976-77. (1976). Journal of the American Oil Chemists’ Society, 53(7), 426A–427A. doi:10.1007/bf02636806.
Miliauskas, G., Venskutonis, P. R., & van Beek, T. A. (2004). Screening of radical scavenging activity of some medicinal and aromatic plant extracts. Food Chemistry, 85(2), 231–237. doi:10.1016/j.foodchem.2003.05.007.
Tel, G., Öztürk, M., Duru, M. E., Harmandar, M., & Topçu, G. (2010). Chemical composition of the essential oil and hexane extract of Salvia chionantha and their antioxidant and anticholinesterase activities. Food and Chemical Toxicology, 48(11), 3189–3193. doi:10.1016/j.fct.2010.08.020.
Adlercreutz, H., Bannwart, C., Wähälä, K., Mäkelä, T., Brunow, G., Hase, T., … Vickery, L. E. (1993). Inhibition of human aromatase by mammalian lignans and isoflavonoid phytoestrogens. The Journal of Steroid Biochemistry and Molecular Biology, 44(2), 147–153. doi:10.1016/0960-0760(93)90022-o.
Kurzer, M. S., & Xia, X. (1997). Dietary Phytoestrogens Annu Rev Nutr. 17, 353–381.
Maggiolini, M., Bonofiglio, D., Marsico, S., Panno, M. L., Cenni, B., Picard, D., & Andò, S. (2001). Estrogen receptor α mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells. Molecular pharmacology, 60(3), 595-602.
Van der Woude, H., ter Veld, M. G. R., Jacobs, N., van der Saag, P. T., Murk, A. J., & Rietjens, I. M. C. M. (2005). The stimulation of cell proliferation by quercetin is mediated by the estrogen receptor. Molecular Nutrition & Food Research, 49(8), 763–771. doi:10.1002/mnfr.200500036.
Mueller, S. O., Clark, J. A., Myers, P. H., & Korach, K. S. (2002). Mammary Gland Development in Adult Mice Requires Epithelial and Stromal Estrogen Receptor α. Endocrinology, 143(6), 2357–2365. doi:10.1210/endo.143.6.8836.
DOI: 10.28991/SciMedJ-2019-0101-4
Refbacks
- There are currently no refbacks.
Copyright (c) 2019 habibeh zare
